3xTg-AD saguek dimorfismo sexuala erakusten dute portaeran

Abstract

3xTg-AD mice are valuable animal models for studying Alzheimer's disease (AD), as they exhibit age-related cognitive decline and behavioral alterations. Sex is a relevant factor in AD, with women presenting a higher risk of developing the condition and experiencing faster cognitive decline. In this study, we examined anxiety-like behavior and spatial and emotional memory in 12-month-old WT and 3xTg-AD mice, with a focus on sex differences. The results revealed prominent behavioral alterations in 3xTg-AD mice, alongside test-dependent sexual dimorphism. These findings contribute to a better understanding of AD and highlight the importance of considering sex differences in AD research.