miR-33a- eta miR-27b-ren inplikazioa estatinen efektu diabetogenikoan

Authors

  • Telmo Santamaria-Zamorano University of the Basque Country (UPV/EHU)
  • Beñat Larrañaga-Monasterio University of the Basque Country (UPV/EHU)
  • Aitor Ordeñana-Manso University of the Basque Country (UPV/EHU)
  • Endika Cabrera-Antón University of the Basque Country (UPV/EHU)
  • Shifa Jebari-Benslaiman University of the Basque Country (UPV/EHU)
  • Kepa B Uribe University of the Basque Country (UPV/EHU)
  • Asier Benito-Vicente University of the Basque Country (UPV/EHU)
  • Asier Larrea-Sebal University of the Basque Country (UPV/EHU)
  • Cesar Martin University of the Basque Country (UPV/EHU)
  • Unai Garcia-Galicia University of the Basque Country (UPV/EHU)

DOI:

https://doi.org/10.26876/ikergazte.vi.05.24

Keywords:

Statins, type two diabetes, microRNA, adipocytes, cardiovasular diseases

Abstract

Cardiovascular diseases (CVD), a wide range of heart and blood vessels affections, are the leading cause of death worlwide. Lipid deposits in the arteries are one of the main factors in the developtment and complications of CVDs. Statins are the gold standard treatment when dealing with atheromatous plaque, but evidence has shown that they can end up causing type two diabetes mellitus (T2DM). To elucidate this diabetogenic mechanism, 3T3-L1 adipocytes were treated with different statines, in orden the address changes in glucose homeostasis and insulin resistante related gene expressions and microRNAs. miR-33a and miR-27b overexpression leads to a decrease in the expression of these genes, favoring T2DM development.

License

Copyright (c) 2025 IkerGazte. Nazioarteko ikerketa euskaraz

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Downloads

Published

2025-05-30

How to Cite

Santamaria-Zamorano, T., Larrañaga-Monasterio, B., Ordeñana-Manso, A., Cabrera-Antón, E., Jebari-Benslaiman, S., B Uribe, K., Benito-Vicente, A., Larrea-Sebal, A., Martin, C., & Garcia-Galicia, U. (2025). miR-33a- eta miR-27b-ren inplikazioa estatinen efektu diabetogenikoan. IkerGazte. Nazioarteko Ikerketa Euskaraz, 5, 195–202. https://doi.org/10.26876/ikergazte.vi.05.24

Conference Proceedings Volume

Vol. 5 (2025): VI. Ikergazte. Nazioarteko ikerketa euskaraz. Kongresuko artikulu bilduma. Zientziak eta Natura Zientziak

Section

Artikuluak

Categories