HDL berreraikien erabilera plasma lipoproteinen dinamikak aztertzeko

Abstract

Cardiovascular diseases are currently the leading cause of death, and HDL particles play a fundamental role in cholesterol efflux. Reconstituted HDL (rHDL) nanoparticles, designed to mimic HDL particles, are being investigated as potential therapeutic agents. In this study, DPPC-based rHDL particles were synthesized and incubated with human plasma to analyze their acquisition of proteins and lipids. They were isolated using fluorescent labelling and sequential chromatography, and proteomic results showed that they acquire apolipoproteins commonly found in natural HDL. This indicates that rHDLs have the capacity to mimic HDL particles and could open new avenues for cardiovascular therapies.