RNA luze ez-kodetzaileen (lncRNA) funtzioa haurdunaldiaren galera errepikakorrean (RPL)

Abstract

This study explores the role of long non-coding RNAs (lncRNAs) in female reproductive diseases, with a focus on Recurrent Pregnancy Loss (RPL). Previously considered non-functional, recent findings reveal that lncRNAs regulate gene expression through various mechanisms. This research involved reviewing relevant literature and collecting high-throughput RNA sequencing (RNA seq) data of tissue samples from villus, decidual immune cells, endometrium, and decidua from women affected by RPL and a control group. Quality filters and differential expression analysis highlighted key lncRNAs associated with RPL. Furthermore, functional analysis indicated that these lncRNAs are involved in inflammation and immune response pathways, which are known to be crucial for pregnancy maintenance. These findings suggest that lncRNAs could be potential therapeutic targets for RPL or even used for early diagnosis.