CEMIPek hantura iraunarazten du larruazaleko melanoman azido hialuronikoaren metabolismoaren bidez

Abstract

High molecular weight hyaluronic acid (HMW-HA) is a key anti-fibrotic and antiinflammatory component of the extracellular matrix, while low molecular weight HA (LMW-HA) has pro-inflammatory properties. Increased CEMIP expression (Cell migration inducing protein), a novel hyaluronidase, has been linked to diseases characterized by chronic inflammation (i.e. osteoarthritis and cancer). Cutaneous melanoma occurs in the skin that is rich in HA and dissemination of the primary tumor remains the principal clinical challenge. CEMIP expressing melanoma cells foster an inflammatory microenvironment by procuring low MW HA species and inducing the expression of pro-inflammatory cytokines in dermal fibroblasts.