Dislipidemiaren aurkako tratamendu berriak nanopartikulak erabiliz

Authors

  • Ane San José University of the Basque Country (UPV/EHU)
  • Asier Larrea University of the Basque Country (UPV/EHU)
  • Shifa Jebari University of the Basque Country (UPV/EHU)
  • Unai Galicia University of the Basque Country (UPV/EHU)
  • Asier Benito University of the Basque Country (UPV/EHU)
  • Kepa Uribe University of the Basque Country (UPV/EHU)
  • Cesar Martin University of the Basque Country (UPV/EHU)

DOI:

https://doi.org/10.26876/ikergazte.v.05.48

Keywords:

ApoE protein, nanoparticles, hypercholesterolemia, siRNA, statins, bempedoic acid

Abstract

Hypercholesterolemia is the most frequent dyslipidemia and is characterized by its high level of Low-density Lipoprotein cholesterol (LDL-C) in blood. High LDL-C levels are directly related to the risk of developing cardiovascular diseases, so it is important to develop new therapies to treat this disease. The objective of this study was to develop ApoE protein based nanoparticles to improve the efficacy of treatments with bempedoic acid, statins and small interfering RNA (siRNA). In fact, the uptake of LDL and low-density lipoprotein receptor (LDLr) expression have been quantified after treatment testing and significant results have been obtained.

License

Copyright (c) 2023 Ane San José, Asier Larrea, Shifa Jebari, Unai Galicia, Asier Benito, Kepa Uribe, Cesar Martin

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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Published

2023-05-09

How to Cite

San José, A., Larrea, A., Jebari, S., Galicia, U., Benito, A., Uribe, K., & Martin, C. (2023). Dislipidemiaren aurkako tratamendu berriak nanopartikulak erabiliz. IkerGazte. Nazioarteko Ikerketa Euskaraz, 5, 377–384. https://doi.org/10.26876/ikergazte.v.05.48

Conference Proceedings Volume

Vol. 5 (2023): V. Ikergazte. Nazioarteko ikerketa euskaraz. Kongresuko artikulu bilduma. Zientziak eta Natura Zientziak

Section

Artikuluak

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