RNA luze ez kodetzaileak hesteetako hanturazko gaixotasunean

Abstract

Cytokine mediated sustained inflammation increases the risk to develop different complex chronic inflammatory diseases, such as inflammatory bowel disease. Recent studies highlighted the involvementof inflammation associated gene variants in m6A methylation. Moreover, long noncoding RNAs participate in the pathogenesis of inflammatory disorders and their function can be influenced by differential methylation. Here we describe the functional implication of LOC339803 long noncoding RNA in the development of inflammatory bowel disease. Overall, our results support LOC339803 as an important mediator of intestinal inflammation and we present this long noncoding RNA as a potential novel therapeutic target for the treatment of inflammatory bowel disease.