Relation between atmospheric pollution exposure while pregnant and thyroxin-level at birth, INMA-Gipuzkoa

Abstract

Thyroid hormones are affected by atmospheric pollution, as it is shown in research papers published in recent years. The aim of this study is to assess the relation between the fine particles (PM_2.5) and nitrogen dioxide (NO₂) exposure while pregnant, on the heel blood T4 total thyroid hormone of the newborns. For that purpose data from INMA cohort-Gipuzkoa were used. Lineal multivariant models were used to estimate the relation. In our study population of normal healthy pregnancies, PM_2.5 exposure during pregnancy was positively associated with higher levels of newborn´s heel blood T4-levels (β= 0.15, CI95%: 0.02; 0.27, p=0.019); the NO₂ exposure was positively but marginally significantly associated with heel blood T4-levels (β= 0.04, IC95%: -0.01; 0.09, p=0.099).