Omega-3 gantz-azidoen eragin neurobabeslea nerabezaroan aldizkako gehiegizko alkohol-kontsumoaren ostean: eikosanoide-endokannabinoide seinaleztapen gurutzatuaren garrantzia

Abstract

Adolescence is a critical period of development, and the brain is highly sensitive to excessive alcohol consumption, such as binge drinking. In alcohol-induced long-term damage, the microglial response and the production of proinflammatory eicosanoids play a key role, with 2-arachidonoylglycerol (2-AG) potentially serving as a major source of proinflammatory eicosanoids. In a mouse model, we examined the effects of alcohol consumption on microglial structure and the expression of monoacylglycerol lipase (MAGL) and cyclooxygenase-2 (COX-2) enzymes involved in eicosanoid synthesis. We also evaluated the ability of omega-3 fatty acids to mitigate these changes. Our results highlight the potential of omega-3 fatty acids in reducing the harmful effects of alcohol consumption.