NEDD4 eta UBE3Aren arteko elkarrekintzaren azterketa Angelman sindromearen testuinguruan

Abstract

Angelman syndrome (AS) is a complex and severe neurodevelopmental disorder that results from the loss of UBE3A E3 ubiquitin-protein ligase function in the brain. Knowing the identity and ubiquitination patterns of UBE3A substrates is necessary for a better understanding of AS and the search for new therapeutic strategies. With the expectation that the results obtained in the validation of the potential substrate EAAT2 can be explained by investigating the relationship between NEDD4 and UBE3A, and these results may contribute to a better understanding of AS, the aim of this work is to validate NEDD4 as an interactor and substrate of UBE3A in human HEK293T cells. Although it has not been possible to explain the interaction between NEDD4 and UBE3A, there are sufficient results to continue the study.