Aterosklerosi plakako kolesterol kristalak disolbatu ditzakeen nanopartikula lipidiko bidezko terapia berritzailea

Authors

  • Beñat Larrañaga-Monasterio University of the Basque Country (UPV/EHU)
  • Endika Cabrera-Antón University of the Basque Country (UPV/EHU)
  • Aitor Ordeñana-Manso University of the Basque Country (UPV/EHU)
  • Telmo Santamaría-Zamorano University of the Basque Country (UPV/EHU)
  • Shifa Jebari-Benslaiman University of the Basque Country (UPV/EHU)
  • Kepa B. Uribe University of the Basque Country (UPV/EHU)
  • Unai Galicia-Garcia University of the Basque Country (UPV/EHU)
  • Asier Larrea-Sebal University of the Basque Country (UPV/EHU)
  • Cesar Martin University of the Basque Country (UPV/EHU)
  • Asier Benito-Vicente University of the Basque Country (UPV/EHU)

DOI:

https://doi.org/10.26876/ikergazte.vi.04.24

Keywords:

rHDL, cholesterol, atherosclerotis, inflamation

Abstract

Among the strategies for treating atherosclerosis, the use of lipidic nanoparticles has gained significant attention. This study investigates the ability of rHDL and LNP nanoparticles, which resemble nascent HDL, to dissolve cholesterol crystals and their effect on the inflammatory response. Biophysical characterization of the nanoparticles confirmed their homogeneous and stable structure. Furthermore, in vitro results demonstrated that these nanoparticles effectively dissolve cholesterol crystals and significantly reduce inflammatory markers in J774A.1 macrophages. Consequently, these nanoparticles could represent an innovative therapeutic strategy for the treatment of atherosclerosis.

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Copyright (c) 2025 IkerGazte. Nazioarteko ikerketa euskaraz

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This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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Published

2025-05-30

How to Cite

Larrañaga-Monasterio, B., Cabrera-Antón, E., Ordeñana-Manso, A., Santamaría-Zamorano, T., Jebari-Benslaiman, S., B. Uribe, K., Galicia-Garcia, U., Larrea-Sebal, A., Martin, C., & Benito-Vicente, A. (2025). Aterosklerosi plakako kolesterol kristalak disolbatu ditzakeen nanopartikula lipidiko bidezko terapia berritzailea. IkerGazte. Nazioarteko Ikerketa Euskaraz, 4, 201–208. https://doi.org/10.26876/ikergazte.vi.04.24

Conference Proceedings Volume

Vol. 4 (2025): VI. Ikergazte. Nazioarteko ikerketa euskaraz. Kongresuko artikulu bilduma.Osasun Zientziak

Section

Artikuluak

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