Erdialdeko habenularen parte-hartzea emozioen fisiopatologian

Authors

  • Lucía Sangroniz-Beltrán University of the Basque Country (UPV/EHU)
  • Nahia López de Murga University of the Basque Country (UPV/EHU)
  • Alaitz Mujika-Peñacoba University of the Basque Country (UPV/EHU)
  • Cathaysa Rodríguez-Cedrés University of the Basque Country (UPV/EHU)
  • Paula Torres-Maldonado Achucarro
  • Pablo Reyes-Velásquez Achucarro
  • María Ceprián Achucarro
  • Jon Egaña-Huguet University of the Basque Country (UPV/EHU)
  • Edgar Soria-Gómez Ikerbasque, Foundation for Science

DOI:

https://doi.org/10.26876/ikergazte.vi.04.17

Keywords:

medial habenula, CB1R, depression, endocannabinoids, microglia, astrocytes

Abstract

Habenular nuclei link and regulate brain structures crucial for different motivational and cognitive states. In addition to neurons, glial cells (astrocytes, microglia and oligodendrocytes) that express CB1R in the plasmatic membrane also participate in these processes. In this work, the effect of changes in the glial cells, astrocytes and microglia, of the medial habenula has been studied. To do so, on one hand, CB1R has been eliminated in the astrocytes of mice and, on the other hand, models of mice depression have been studied. The response of these mice to negative stimuli has been studied using behavioral tests. After these, the counting and morphology analysis of glial cells, astrocytes and microglia, was done. Results suggest that the astrocytes and microglia cells of the medial habenula are involved in the mechanisms of behavioral changes.

Downloads

Published

2025-05-30

How to Cite

Sangroniz-Beltrán, L., de Murga, N. L., Mujika-Peñacoba, A., Rodríguez-Cedrés, C., Torres-Maldonado, P., Reyes-Velásquez, P., Ceprián, M., Egaña-Huguet, J., & Soria-Gómez, E. (2025). Erdialdeko habenularen parte-hartzea emozioen fisiopatologian. IkerGazte. Nazioarteko Ikerketa Euskaraz, 4, 145–152. https://doi.org/10.26876/ikergazte.vi.04.17