Antzutasun maskulinoa duten pazienteen estratifikaziorako biomarkatzaile metabolikoen bilaketa eta tresna diagnostiko baten garapena

Abstract

Nowadays, human infertility affects approximately 17.5% of the global population and in 50% of cases, it is due to a male factor. Furthermore, diagnostic tools for male infertility have many limitations, as they are not 100% effective and involve the destruction of the male gametes. Metabolic and lipidomic studies could be of great use for evaluating semen quality, allowing us to have a more comprehensive and integrated molecular characterization of the underlying causes of male infertility. Additionally, the identification of metabolic biomarkers in seminal fluid could enable us to perform a diagnostic test on the same seminal sample without destroying the spermatozoa.