Epe luzerako ondorioak loki-lobuluko epilepsia sagu-eredu baten garunean

Abstract

Temporal lobe epilepsy is the most common type of epilepsy in adults. Although available anticonvulsants reduce the excessive neuronal excitability, they are not always effective. Nowadays research focuses on the control of neuroinflammatory mechanisms switched on in epilepsy. Hence, non-neuronal brain cells and the endocannabinoid system have emerged as potential targets because the role of this system in neuroinflammation mediated by cannabinoid receptor-expressing glial cells. We show changes in glial cells and the cannabinoid 1 (CB1) receptor, the main target of endogenous and exogenous cannabinoids, throughout brain regions in a mouse model of temporal lobe epilepsy. Remarkably, these anatomical changes impact on cognition (memory) and behavioral states (anxiety).