Endometriosis and anthropometric and menstrual traits: searching for common genetic roots

Authors

  • Aiara Garitazelaia González Genetika, Antropologia Fisikoa eta Animalien Fisiologia Saila, Medikuntza eta Erizaintza Fakultatea, Euskal Herriko Unibertsitatea (UPV/EHU)
  • Jose Ramon Bilbao Genetika, Antropologia Fisikoa eta Animalien Fisiologia Saila, Medikuntza eta Erizaintza Fakultatea, Euskal Herriko Unibertsitatea (UPV/EHU)
  • Nora Fernandez-Jimenez Genetika, Antropologia Fisikoa eta Animalien Fisiologia Saila, Medikuntza eta Erizaintza Fakultatea, Euskal Herriko Unibertsitatea (UPV/EHU)
  • Iraia García-Santisteban Genetika, Antropologia Fisikoa eta Animalien Fisiologia Saila, Medikuntza eta Erizaintza Fakultatea, Euskal Herriko Unibertsitatea (UPV/EHU)

DOI:

https://doi.org/10.26876/osagaiz.2.2021.417

Keywords:

Endometriosis, mendelianrandomization, anthropometrictraits, menstrual traits

Abstract

Endometriosis, of unknown cause, is one of the most prevalent gynecological diseases, characterized by the presence of functionally active endometrial tissue outside the womb. It has been associated with many phenotypes, such as anthropometric and menstrual traits. However, whether these traits and endometriosis share common genetic roots is still undetermined. To investigate this, we performed a two-sample mendelian randomization (2SMR) analysis, using public data from GWAS studies. Our results showed a genetic link between low weight and shorts menstrual cycles and endometriosis. Furthermore, it seems that this relationship could be causal.

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Published

2021-12-31

How to Cite

Garitazelaia González, A., Bilbao, J. R., Fernandez-Jimenez, N., & García-Santisteban, I. (2021). Endometriosis and anthropometric and menstrual traits: searching for common genetic roots. Osagaiz: Osasun-Zientzien Aldizkaria, 5(2). https://doi.org/10.26876/osagaiz.2.2021.417

Issue

Vol. 5 No. 2 (2021)

Section

Lan sarituak