Pathophisiology of atherosclerosis: from endothelial dysfunction to plaque rupture
DOI:
https://doi.org/10.26876/osagaiz.1.2024.575Keywords:
atherosclerosis, atheroma plaque, stroke, cardiovascular diseaseAbstract
Atherosclerosis, the main risk factor for cardiovascular disease, is initiated by endothelium activation and followed by a cascade of events such as accumulation of lipids, fibrous elements and calcification. These processes trigger atheroma plaque formation and activation of inflammatory pathways. These processes along with the resulting vessel narrowing could promote cardiovascular clinical complications. This review summarizes the different stages of atherosclerosis development, ranging from endothelial dysfunction to plaque rupture, along with current treatment of the disease.
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